Synthesis of complex compounds of the monoammonium salt of glycyrrhizic acid and thiourea

With poor (low) solubility in the aquatic environment, highly toxic drugs (aspirin, doxorubicin, daunorubicin, sulfonamides and others), a low level of glycyrrhizic acid (HA) leads to decrease toxicity increases their biological activity due water. The stability constants (stability) value Gibbs energy synthesized supramolecular complex have been calculated, theoretical experimental research methods were used determine conditions for obtaining complexes thiourea. These researches carried out as part joint work study effect medicines on living organism, under an interuniversity program between Andijan State University Tashkent Pharmaceutical Institute Republic Uzbekistan. aim is constant monoammonium salt (MASHA) with thiourea energy. To structure composition resulting MASHA thiourea, UV IR spectroscopy isomolar series method used.